Bioactive Small Molecules
Medchemexpress LLC VEGFR-1 Human 328a 100ug
The VEGFR-1 protein is a tyrosine protein kinase that acts as a cell surface receptor for VEGFA VEGFB and PGF It plays a crucial role in embryonic vasculature development regulation of angiogenesis cell survival migration macrophage function chemotaxis and cancer cell invasion VEGFR-1 Protein Human (328a a HEK293 His) is the recombinant human-derived VEGFR-1 protein expressed by HEK293 with C-His labeled tag
Enzo Life Sciences Ac-LEVD-CHO (1mg)
Inhibitor of caspase-4 and -5. Reversible inhibitor of caspase-4. Also inhibits caspase-5. Alternative name: Caspase 4 inhibitor (aldehyde). Formula: C22H36N4O9. MW: 500.6. Purity: ≥95% (HPLC). Appearance: White powder. Formulation: Lyophilized. Peptide content: 70-90%. Solubility: Soluble in distilled water. Long Term Storage: -20°C. Use/Stability: Stock solutions should be divided into aliquots and stored at -20°C. Handling: Keep cool and dry.
Medchemexpress LLC 2,5-Dihydroxybenzoic acid | 490-79-9 | 154.12 | 1 ML
2,5-Dihydroxybenzoic acid is an analytical standard and a derivative of benzoic acid, intended for research and analytical applications. This compound acts as a powerful inhibitor of fibroblast growth factors, a reactive oxygen species (ROS) scavenger, and an antioxidant. It has demonstrated anti-proliferative activity in human breast cancer cells and inhibits tumor growth in mice with advanced gastric cancer.
- Analytical standard for research and analytical applications
- Derivative of benzoic acid
- Powerful inhibitor of fibroblast growth factors
- Reactive oxygen species (ROS) scavenger
- Antioxidant, protecting cells against oxidative damage
- Exhibits anti-proliferative activity in human breast cancer cells
- Inhibits tumor growth in mice with advanced gastric cancer
Medchemexpress LLC Guretolimod (hydrochloride) | 98.7% | 550.01 | 100 MG
Guretolimod hydrochloride is a Toll-like receptor 7 (TLR7) agonist, suitable for research applications. It is supplied as an off-white to light yellow solid.
- Targets toll-like receptor 7 (TLR7)
- Appears as an off-white to light yellow solid
- Recommended storage at -20°C, sealed, away from moisture and light
- Soluble in DMSO at 100 mg/mL (181.81 mM)
- For research use only
Medchemexpress LLC FITC-Chitosan | 95.0% | 100000 | 100 MG
FITC-Chitosan (MW 100000) is a Chitosan labeled with FITC. It can be used for fluorescent labeling and imaging.
- Used for fluorescent labeling and imaging.
Cayman Chemical -PInoresInol 5mg
A lignan with diverse biological activities; an inhibitor of α-glucosidase and maltase (IC50s = 492 and 34.3 µM in Baker’s yeast and rat small intestine, respectively); scavenges ABTS, but not DPPH, radicals in cell-free assays (IC50s = 13.43 and >200 UG/ml, respectively); cytotoxic to A549, HepG2, and MCF-7, but not U251 and Bcap-37, cells (IC50s = 29.35, 62.35, 75.32, >80, and >80 µM, respectively); prevents cell death induced by glutamate in HT22 cells (EC50 = 6.96 µM) and inhibits LPS-induced nitric oxide production in RAW 264.7 cells (IC50 = 7.89 µM)
Medchemexpress LLC HY-116872 5mg Medchemexpress, MAC13772 CAS:4871-40-3 Purity:>98%
Medchemexpress, HY-116872 5mg MAC13772 CAS:4871-40-3 MAC13772 is a potent inhibitor of the enzyme BioA (IC50=250 nM), the antepenultimate step in biotin biosynthesis. MAC13772 is a novel antibacterial compound. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY TH-302 25mg
A hypoxia-activated prodrug and DNA alkylating agent with anticancer activity; selectively cytotoxic to H460 human NSCLC cells grown under hypoxic over normoxic conditions (IC50s = 0.019 and 5.1 μM, respectively); reduces survival of H460 and HT-29 cells in a clonogenic assay (IC50s = 0.2 and 0.2 μM, respectively); inhibits primary tumor growth by 41% in an MIA PaCa-2-RFP mouse orthotopic xenograft model at 33 mg/kg per day; inhibits tumor growth in the Calu-6 NSCLC, H82 small cell lung, A375 melanoma, PC-3 prostate, and BxPC-3 pancreatic cancer mouse xenograft models at 50 mg/kg
Medchemexpress LLC HY-A0070A 100mg , Liothyronine CAS:6893-02-3 Purity:>98%
HY-A0070A 100mg Liothyronine CAS: 6893-02-3 Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC BAY885 | 2307249-33-6 | 99.3% | 515.53 | 1 ML
BAY885 is a chemical probe, characterized as a highly potent and selective ERK5 inhibitor with an IC50 of 35 nM. It exhibits weak inhibition on other kinases.
- Highly potent and selective ERK5 inhibitor.
- Exhibits an IC50 of 35 nM for ERK5.
- Shows weak inhibition on other kinases.
- The ERK5 probe 41 demonstrated potent ERK5 kinase and transcriptional inhibition in the SN12C-MEF2 reporter cell line (IC50 = 115 nM/IC90 = 691 nM).
- No effects observed on a reporter control cell line with constitutive luciferase expression (SN12C-CMV-luc, IC50 > 30 μM).
Medchemexpress LLC 6-methyluracil | 626-48-2 | MFCD00006028 | 99.7% | 126.11 | C5H6N2O2 | 50g
6-Methyluracil (Pseudothymine) a metabolite of Uracil can be used as an indicator of acetoacetyl-CoA (AACoA) accumulation 6-Methyluracil exhibits antiradiation effect in vivo[1][2]
Medchemexpress LLC SIRT5 inhibitor 1 | 2166487-21-2 | 99.7% | 674.81 | 5 MG
SIRT5 inhibitor 1 is a potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. This compound is described as a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1.
- Potent human sirtuin 5 deacylase inhibitor
- IC50 of 0.11 μM
- Target: Sirtuin
- Pathways: Cell Cycle/DNA Damage; Epigenetics
- For research use only
- Appearance: White to off-white solid
- Molecular formula: C31H39FN6O6S2
- Storage powder: -20°C for 3 years, 4°C for 2 years
- Storage in solvent: -80°C for 2 years, -20°C for 1 year
Cayman Chemical ANTIBODY ZnamIvIr 1mg
An inhibitor of influenza neuraminidase; inhibits neuraminidase activity in clinical isolates of influenza A subtypes H1N1 and H3N2 and influenza B (geometric mean IC50s = 0.73, 1.64, and 11.21 nM, respectively); inhibits replication of influenza A and B in isolated human respiratory epithelial cells (EC90s = <0.01 mg/L and 0.25-0.54 mg/L, respectively); reduces lung viral titers in mice infected with influenza A or B at 0.4 mg/kg intranasally
![Medchemexpress LLC Methanone, [6-methoxy-2-[4-methoxy-3-(phosphonooxy)phenyl]-1H-indol-3-yl](3,4,5-trimethoxyphenyl) | 288847-41-6 | 99.5% | 587.42 g·mol⁻1 | C26H24NNa2O10P | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000238271.png-250.jpg)
Medchemexpress LLC Methanone, [6-methoxy-2-[4-methoxy-3-(phosphonooxy)phenyl]-1H-indol-3-yl](3,4,5-trimethoxyphenyl) | 288847-41-6 | 99.5% | 587.42 g·mol⁻1 | C26H24NNa2O10P | 100MG
OXi8007 is a water-soluble phosphate prodrug that acts as a tubulin/microtubule-binding inhibitor for research applications. It is supplied as the disodium phosphate salt with high analytical purity and is intended for in vitro research use only. Key chemical identifiers include CAS 288847-41-6, formula C26H24NNa2O10P, and molecular weight 587.42 g·mol⁻1.
- Tubulin/microtubule binding mechanism suitable for anti-microtubule studies.
- High purity: 99.5%.
- Solid, off-white to light yellow appearance; phosphate salt increases aqueous solubility.
- Chemical formula C26H24NNa2O10P and molecular weight 587.42 g·mol⁻1.
- Available in multiple solid masses and solution formats for assay flexibility.
- Recommended storage: 4°C sealed; in solvent: -80°C (up to 6 months) or -20°C (up to 1 month), sealed, away from moisture and light.
- For research use only; not for human or clinical use.
Medchemexpress LLC Cdk9 inhibitor HH1 | 204188-41-0 | 99.7% | 261.34 g/mol | C13H15N3OS | 5MG
CDK9 inhibitor HH1 is a potent, selective small-molecule inhibitor of cyclin-dependent kinase 9 (CDK9) used in biochemical and cellular research to study transcriptional regulation and cancer biology.
- Potent and selective CDK9 inhibition.
- Inhibits CDK9-mediated transcription.
- Suitable for cancer biology and transcription research.
- Molecular formula C13H15N3OS; molecular weight 261.34 g·mol⁻1.
- Purity approximately 99.7% as reported.
- Appearance: light yellow to yellow solid.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Available pack sizes: 5 mg, 10 mg, 50 mg, 100 mg.